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  • Citicoline Capsules - 500 mg CDP-Choline High Dose | 60 Capsules Packshot
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Citicoline Capsules - 500 mg CDP-Choline High Dose | 60 Capsules

Citicoline Capsules - 500 mg CDP-Choline High Dose | 60 Capsules

Citicoline capsules - 500 mg CDP-choline in just one capsule a day, manufactured and lab-tested in Austria.

  • 500 mg citicoline (CDP-choline) per capsule = per daily dose - chemically cytidine 5'-diphosphocholine
  • EU maximum amount: 500 mg per day is the amount for which citicoline is authorised as a novel food in food supplements in the EU
  • Study-based dosage: 500 mg citicoline per day has been investigated in randomised, placebo-controlled human studies
  • Raw material purity ≥ 98% - tested by HPLC, including heavy metal and microbiological analysis
  • Vegan - plant-based capsule shell made of hydroxypropyl methylcellulose (HPMC)
  • 60 capsules = 60 days - 1 capsule daily

22,95 €
48,83 € 100g
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Citicoline Capsules - 500 mg CDP-Choline High Dose | 60 Capsules

Citicoline (CDP-choline) - the body's own compound of cytidine and choline

  • Citicoline, chemically cytidine 5'-diphosphocholine (CDP-choline for short), is a nucleotide that occurs naturally in the cells of the human body. It consists of the building blocks cytidine and choline, linked by a diphosphate bridge (molecular formula C14H26N4O11P2).
  • In metabolism, citicoline is an intermediate of the so-called Kennedy pathway - the synthesis route cells use to form phosphatidylcholine, a main component of cell membranes. It is named after the biochemist Eugene P. Kennedy, who described CDP-choline in the 1950s.
  • After intake, citicoline is split into choline and cytidine; in humans, blood levels of choline and above all uridine rise, as a pharmacokinetic study showed (Wurtman et al., 2000).

500 mg citicoline with ≥ 98% purity - study-based dosage

  • Green Naturals Citicoline contains 500 mg CDP-choline in a single capsule per day - compared with many multi-ingredient products in which citicoline is only a minor component without a clearly stated daily amount.
  • The citicoline raw material is specified by HPLC to a content of at least 98% and is additionally tested for heavy metals and microbiology - compared with many suppliers who give no information on the purity of their raw material.
  • 500 mg citicoline per day was investigated in a randomised, double-blind, placebo-controlled 12-week study with 100 healthy older adults (Nakazaki et al., 2021); the review by Grieb (2014) gives an overview of mechanisms and open research questions.

Transparency instead of advertising promises - authorised as a novel food

  • There are currently no authorised health claims for citicoline according to EFSA - which is why we deliberately avoid promises of effects and give you verifiable facts instead.
  • Citicoline has been authorised in the EU as a novel food since 2014 - for food supplements with up to 500 mg per day, not for children. Green Naturals Citicoline provides exactly this amount with 1 capsule.
  • 60 vegan capsules per tin last for 60 days - a 2-month supply with 1 capsule daily.
Citicoline Capsules - 500 mg CDP-Choline High Dose | 60 Capsules
Citicoline Capsules - 500 mg CDP-Choline High Dose | 60 Capsules

  • Best time to take

    Take 1 capsule daily with sufficient liquid, for example in the morning with breakfast. Regular daily intake is more important than the time of day.

  • Dosage and duration of use

    Daily dose: 1 capsule (= 500 mg citicoline). In studies, citicoline was taken daily for 12 weeks. The pack with 60 capsules lasts for 60 days. Do not exceed the recommended daily dose. Not intended for consumption by children; pregnant and breastfeeding women should consult a doctor or pharmacist before use.
Quality in focus. Find out what makes Green Naturals® Citicoline special in raw material purity, dosage and laboratory testing.
Quality criterion Green Naturals® Other manufacturers
Raw material & purity ✔ Citicoline (CDP-choline) with ≥ 98% purity (HPLC) ✕
Sensible dosage ✔ 500 mg per daily dose - EU maximum for food supplements ✕
Research ✔ 500 mg per day investigated in randomised human studies ✕
Laboratory testing ✔ heavy metals & microbiology tested, batch documented ✕
Legal certainty ✔ EU-authorised novel food, no unauthorised claims ✕
Formula & tolerability ✔ vegan HPMC capsule ✕
Transparency & responsibility ✔ clear notes on children, pregnancy & breastfeeding ✕
Practicality ✔ 1 capsule daily, 60 capsules = 60 days ✕

Our vision at Green Label® is to create products based on purity and transparency. Our approach is to source high-quality raw materials directly from leading producers worldwide to offer a product that is uncompromisingly committed to natural ingredients. Every capsule of our products carries the promise of purity, sustainability, and maximum effectiveness:

  • Premium active ingredients as pure substances, directly from leading producers.
  • Production and bottling under the highest pharmaceutical standards (GMP, ISO 22000:2018, HACCP).
  • Maximum avoidance of all additives; only valuable natural substances are used.
  • Vegan capsule shells, 100% free of PEG and other undesirable substances.
  • Packaging in environmentally friendly, non-toxic materials for optimal aroma protection.

My name is Dr. Hari Sven Krishnan, founder of Heilpflanzenwohl GmbH and chief pharmacist.

Together with an experienced team of specialists, including Stephan Walz (pharmacist), Marie Schröder (nutritional scientist), and Dr. Christiane Gras (immunologist), we developed Green Naturals.

The result of intensive research with a clear goal: to offer you natural, highly effective products. At Heilpflanzenwohl, quality and purity come first, because we are convinced: "The best medicine comes from nature – we just need to learn how to use it correctly."

Food supplement based on citicoline
Ingredients: Citicoline, capsule shell: glazing agent (hydroxypropyl methylcellulose).
Ingredients 1 capsule / day *NRV %
Citicoline 500 mg **
* NRV % = Nutrient Reference Values according to Regulation (EU) No 1169/2011
** no reference available
Recommended Use: Daily dose: 1 capsule (= 500 mg citicoline). In studies, citicoline was taken daily for 12 weeks. The pack with 60 capsules lasts for 60 days. Do not exceed the recommended daily dose. Not intended for consumption by children; pregnant and breastfeeding women should consult a doctor or pharmacist before use.
Notes: Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the stated recommended daily dose. Keep out of reach of young children. Store in a cool, dry place protected from light. Not intended for consumption by children. Pregnant women and breastfeeding women should consult a doctor or pharmacist before taking this product.
Net quantity ℮: 47,0 g

What is citicoline?

Citicoline is a compound naturally present in the body, made of the building blocks cytidine and choline - chemically cytidine 5'-diphosphocholine. The body uses it as an intermediate in the formation of phosphatidylcholine, a main component of cell membranes. In food supplements, citicoline is used as a high-purity raw material - at Green Naturals with a purity of at least 98%.

What is CDP-choline?

CDP-choline is short for cytidine diphosphate choline and a synonym for citicoline - it is the same compound. The spellings citicholine or citicolin are also common. Branded ingredients such as Cognizin® are also citicoline; what matters for quality is the content, purity and laboratory testing of the raw material.

What is citicoline good for?

Citicoline provides the body with the building blocks choline and cytidine, which it uses to form phosphatidylcholine. In research, citicoline is mainly investigated in connection with brain metabolism, for example in a placebo-controlled study with 500 mg per day (Nakazaki et al., 2021). There are currently no authorised health claims for citicoline according to EFSA.

What is the difference between citicoline and choline?

Choline is a single nutrient, whereas citicoline is a compound of choline and cytidine. After intake, citicoline is split into these two building blocks; in humans, blood levels of choline and above all uridine rise (Wurtman et al., 2000). Citicoline is therefore not simply a choline source, but a distinct substance with two building blocks.

Does citicoline have side effects?

In 2013, EFSA assessed citicoline as safe for the proposed uses and use levels; on this basis it is authorised in the EU for food supplements with up to 500 mg per day. Occasional mild, transient complaints were reported in studies. Stick to the recommended daily dose of 1 capsule and talk to your doctor or pharmacist if you are unsure or take medication.

Can you take citicoline during pregnancy?

Pregnant and breastfeeding women should consult a doctor or pharmacist before taking citicoline. Only limited data are available for these life stages. Your doctor can assess whether supplementation makes sense in your situation and will also take your dietary choline intake into account.

Is citicoline suitable for children?

No. Green Naturals Citicoline is not intended for consumption by children. This restriction is part of the EU authorisation of citicoline as a novel food and is therefore stated on the label. Keep the tin out of reach of young children, ideally in a cool, dry place protected from light.

What is the dosage of the citicoline capsules?

The daily dose is 1 capsule with 500 mg citicoline (CDP-choline). This amount corresponds to the maximum for which citicoline is authorised in food supplements in the EU and has also been used in human studies. One tin with 60 capsules lasts for 60 days. Do not exceed the recommended daily dose.

When should you take citicoline?

Take 1 capsule daily with sufficient liquid - many users choose the morning, for example with breakfast. A fixed time makes regular intake easier. Whether you take the capsule with a meal or on an empty stomach is up to your own tolerance. In studies, citicoline was taken daily over a period of 12 weeks.

Can the capsules be opened?

Yes. The vegan HPMC capsule can be carefully pulled apart; the contents can then be stirred into water, juice or yoghurt. Consume the mixture immediately after preparing it. The easiest way, however, is to swallow the whole capsule with sufficient liquid - this keeps the 500 mg dose exact.

Is the product completely natural?

Citicoline is a compound that occurs naturally in the human body. For food supplements, the raw material is produced in high purity and tested by HPLC for at least 98% citicoline. The capsule shell is made of plant cellulose (HPMC) - the product is vegan and is manufactured and lab-tested in Austria.

Is citicoline authorised in the EU?

Yes. Citicoline has been authorised throughout the EU as a novel food since 2014 (Implementing Decision 2014/423/EU). The authorisation permits up to 500 mg per day in food supplements for adults. Green Naturals Citicoline complies with these requirements and states "Not intended for consumption by children" on the label.

Is citicoline available in pharmacies?

In Germany, Green Naturals® Citicoline with 60 capsules can be ordered from pharmacies under the German pharmacy number PZN 20996510. Outside Germany, it is available from online pharmacies and directly in the Green Naturals online shop. When comparing products, check the amount of citicoline per daily dose and whether the purity of the raw material is stated.

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Sources

  1. Nakazaki, E. et al. (2021). Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. The Journal of Nutrition, 151(8), 2153-2160. DOI: 10.1093/jn/nxab119
  2. Wurtman, R.J. et al. (2000). Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochemical Pharmacology, 60(7), 989-992. DOI: 10.1016/S0006-2952(00)00436-6
  3. Grieb, P. (2014). Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issues. CNS Drugs, 28(3), 185-193. DOI: 10.1007/s40263-014-0144-8
  4. Commission Implementing Decision 2014/423/EU of 1 July 2014 authorising the placing on the market of citicoline as a novel food ingredient under Regulation (EC) No 258/97.

Remarks

  1. HACCP (Hazard Analysis and Critical Control Points) is a preventive system for ensuring food safety that identifies and assesses potential hazards in production and minimizes them through targeted control measures. The seal refers to the manufacturing process.
  2. This is how the grade is calculated: Grade calculation based on star ratings: 5.00 - 4.50 Very good, 4.49 - 3.50 Good, 3.49 - 2.50 Satisfactory, 2.49 - 1.50 Sufficient, 1.49 - 1.00 Poor. For the verification of ratings, no authenticity check of customer reviews is carried out. The ratings are combined from different sources, such as mail-order pharmacies and online marketplaces. Last updated: 19.10.26